Some parts of Deptford today would still be recognisable to them - St Paul's and St. Nicholas' Churches and much of the High Street. But Church Street itself, the earliest actual address I have for my relatives, has very little left from the 19th century with the exception of the Birds Nest pub, with older buildings also on the Broadway near the Church Street junction.
The street seems to take its name not from St Paul's, which was built in the 18th century, but from its older function as the route from the original Deptford settlement near to what is now Deptford Bridge to the parish church of St Nicholas', dating back to the 14th century.
Ideal Homes states that that in the 19th century Church Street was a main shopping street, and as late as the 1970s there were seemingly still significant shops there at the Broadway end (see final photo), but the last remaining older buildings (other than those mentioned above) were demolished in that period, making way for the Lewisham College building and some newer housing on the opposite side of the street. We can though get a sense of pre-demolition Church Street from photographs and paintings.
Also from Ideal Homes is this 1922 painting of Deptford Church Street by Evacustes A. Phipson.
At the always useful Dead Pubs there are these two photographs of a Free House and Off License at 165 Church Street in around 1920. I think the dog might be my dog's great great great grandparent!
Any other stories, memories or pictures of old Church Street very welcome - still can't even work out the 19th century numbering to guess where number 101 might have stood.
(updated 13 April 2011 - see also Deptford Church Street 1881)