Yes, they were filming the new James Bond movie Skyfall, and Daniel Craig was spotted behind the wheel. Judi Dench has also been spotted. Filming has been reported by the Sainsburys on New Cross Road, and on Childers Street/Arklow Road in Deptford. Seemingly the film crew are set up in the car park of the Den (Millwall FC).
Bond fan site MI6 has pictures and more detail. Looks like they are going for the gritty South London railway arch vibe. Filming is continuing so watch out over the weekend.